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Start Over Creator Tintěra, J.

1. Quantification of Intra-Abdominal Fat During Controlled Weight Reduction: Assessment Using the Water-Suppressed Breath-Hold MRI Technique

Creator:
Tintěra, J., Harantová, P., Suchánek, P., Dvořáková, A., Adamová, A., Hájek, M., and Poledne, R.
Type:
article, model:article, and TEXT
Subject:
Intra-abdominal adipose tissue, MRI, and Weight loss
Language:
English
Description:
A group of 14 healthy female subjects was studied using MRI during 2 months of life-style intervention. A series of 21 water-suppressed images was used to determine the intra-abdominal fat volume before and after the controlled loss of weight. The average weight decrease was 8.2 %, but the average relative loss of visceral fat was 20.3 %, whereas subcutaneous fat decreased by 13.4 %. A small but significant increase of insulin sensitivity (decrease in fasting insulin and blood glucose) was observed, but no changes in lipoprotein parameters were demonstrated. There was a significant negative correlation (r=–0.633, p=0.028) between the relative abdominal fat decrease and the initial amount of subcutaneous fat.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. The effect of tryptophan depletion on brain activation measured by functional magnetic resonance imaging during the Stroop test in healthy subjects

Creator:
Horáček, J., Závěšická, L., Tintěra, J., Dockery, C., Platilová, V., Kopeček, M., Španiel, F., Bubeníková, V., and Höschl, C.
Type:
article, model:article, and TEXT
Subject:
Serotonin, Tryptophan depletion, fMRI, Stroop test, and Cognition
Language:
English
Description:
We investigated the role of serotonin in cognitive activation of the frontal cortex. The serotonergic system was affected by the administration of an amino acids mixture without tryptophan (tryptophan depletion). In a placebo-controlled double-blind cross-over study with 20 healthy volunteers, we tested the hypothesis that a tryptophan (serotonin) decrease affects the activation of prefrontal cortex by the Stroop test. Cognitive brain activation was evaluated by functional magnetic resonance imaging (fMRI). Tryptophan depletion decreased the plasma tryptophan level up to 90 % for five hours after the tryptophan-free drink had been consumed when compared with the same mixture with tryptophan (p ≤ 0.0001). Tryptophan depletion did not affect the Stroop test performance. We compared fMRI activation in both conditions (tryptophan depletion and placebo) with plasma tryptophan levels as the covariates. The tryptophan depletion increased the activation (fMRI signal) in the bilateral mediofrontal cortex, anterior cingulate and left dorsolateral prefrontal cortex. The present findings allow the postulate that serotonergic medial forebrain and cingulum bundle pathways play a role in the activity of cortical structures involved in Stroop test processing.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public