This study describes the origin and development of the friendship between the literary scholar Jan Mukařovský (1891–1975) and the writer Vladislav Vančura (1891–1942). Mukařovský’s interpretations of Vančura’s literary works are the main focus of the study. Both Mukařovský’s published works and texts that were never published (e.g. university lectures) are analysed. On the basis of archival research, the author of the study proves that Mukařovský analysed Vančura’s work much earlier than he published his first-ever work on Vančura in 1934. In the course of the 1940s to 1960s, Mukařovský published many texts on Vančura in which he remembered Vančura as a friend, poet, Communist and anti-fascist activist.