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Start Over Creator Jmirko, Yekaterina

1. Polymorphism of detoxification genes and predisposition to the development of Parkinson’s disease in Uzbek individuals

Creator:
Khalimova, Khanifa, Raimova, Malika, Matmurodov, Rustam, Rasulova, Khurshidakhon, Burnasheva, Amina, Jmirko, Yekaterina, and Mukhamedov, Rustam
Format:
braille, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, statistics, and TEXT
Subject:
Parkinsonova nemoc--genetika, polymorfismus genetický, genetická predispozice k nemoci, mutace, výběr pacientů, genetické testování, statistika jako téma, dospělí, staří, staří nad 80 let, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
Language:
English
Description:
According to our research, Uzbek individuals with Parkinson’s disease have high prevalence of 0/0 polymorphisms of GSTT1 and GSTM1 genes, as well as combinations of GSTT1 (0/0)/GSTM1/(0/0) genotypes. These mutations are associated with an earlier debut of the disease, its mixed form, and rapid rate of progression. Determination of mutations in GSTT1 and GSTM1 genes of xenobiotic detoxification in patients with Parkinson’s disease confirms multifactorial nature of this pathology and the role of the influence of various external factors in the modification of clinical signs of disease and its prognosis., Khanifa Khalimova, Malika Raimova, Rustam Matmurodov, Khurshidakhon Rasulova, Amina Burnasheva, Yekaterina Jmirko, Rustam Mukhamedov, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public