Polymorphism of detoxification genes and predisposition to the development of Parkinson’s disease in Uzbek individuals

Title:

Polymorphism of detoxification genes and predisposition to the development of Parkinson’s disease in Uzbek individuals
Polymorphism of detoxification genes and predisposition to the development of Parkinson’s disease in Uzbek individuals

Creator:

Khalimova, Khanifa, Raimova, Malika, Matmurodov, Rustam, Rasulova, Khurshidakhon, Burnasheva, Amina, Jmirko, Yekaterina, and Mukhamedov, Rustam

Contributor:

Khalimova, Khanifa, Raimova, Malika, Matmurodov, Rustam, Rasulova, Khurshidakhon, Burnasheva, Amina, Jmirko, Yekaterina, and Mukhamedov, Rustam

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14045966-0d5a4f8d-675c-451a-aba2-b6384441730d
uuid:bmc14045966-0d5a4f8d-675c-451a-aba2-b6384441730d
local:bmc14045966
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14045966

Subject:

Parkinsonova nemoc--genetika, polymorfismus genetický, genetická predispozice k nemoci, mutace, výběr pacientů, genetické testování, statistika jako téma, dospělí, staří, staří nad 80 let, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

According to our research, Uzbek individuals with Parkinson’s disease have high prevalence of 0/0 polymorphisms of GSTT1 and GSTM1 genes, as well as combinations of GSTT1 (0/0)/GSTM1/(0/0) genotypes. These mutations are associated with an earlier debut of the disease, its mixed form, and rapid rate of progression. Determination of mutations in GSTT1 and GSTM1 genes of xenobiotic detoxification in patients with Parkinson’s disease confirms multifactorial nature of this pathology and the role of the influence of various external factors in the modification of clinical signs of disease and its prognosis., Khanifa Khalimova, Malika Raimova, Rustam Matmurodov, Khurshidakhon Rasulova, Amina Burnasheva, Yekaterina Jmirko, Rustam Mukhamedov, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2011 Volume:2011 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2011