The German University in Prague and natural sciences, 1882-1939. In 1882 the Charles-Ferdinand University in Prague was divided into two separate parts, the Czech and the German. For several decades the research and teaching in natural sciences took place parallely on both of them the paper gives in short retrospective an oveview of same main lines of development. It also offers examples of several academicians whose careers were significant for the German speaking scientific community in Bohemia and Moravia in the second half of the 19th and first half of the 20th century.