Experimentally based models of cardiac cells have been developed since 1960.The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology. and Obsahuje seznam literatury
We investigated seasonal patterns of photosynthetic responses to CO2 concentrations in Spartina alterniflora Loisel, an aerenchymous halophyte grass, from a salt marsh of the Bay of Fundy (NB, Canada), and from plants grown from rhizome in controlled-environment chambers. From late May to August, CO2 compensation concentrations (Γ) of field-grown leaves varied between 2.5-10.7 cm3(CO2) m-3, with a mean of 5.4 cm3(CO2) m-3. From September onwards field leaves showed CO2 compensation concentrations from 6.6-21.1 cm3(CO2) m-3, with a mean of 13.1 cm3 m-3 well into the C3-C4 intermediate range. The seasonal variability in Γ did not result from changing respiration, but rather from a sigmoidal response of net photosynthetic rate (PN) to applied CO2 concentration, found in all tested leaves but which became more pronounced late in the season. One explanation for the sigmoidal response of PN to external CO2 concentration could be internal delivery of CO2 from roots and rhizomes to bundle sheath cells via the aerenchyma, but the sigmoidal responses in S. alterniflora persisted out to the tips of leaves, while the aerenchyma extend only to mid-leaf. The sigmoidicity persisted when CO2 response curves were measured from low to high CO2, or from high to low CO2, and even when prolonged acclimation times were used at each CO2 concentration. and M. O. Bärlocher ... [et al.].