Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms

Title:

Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms

Creator:

Dlouhá, D., Pavel Suchánek, Věra Lánská, and Hubáček, J. A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fceed465-ad93-4d1e-be79-369dc1acd9fc
uuid:fceed465-ad93-4d1e-be79-369dc1acd9fc

Subject:

Fyziologie člověka a srovnávací fyziologie, dietní jídla, tělesná cvičení, polymorfismus, lipidy, glykémie, diet, exercises, polymorphism, lipids, glycemia, intervention, FTO, glycaemia, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Variants within the FTO gene are important determinants of body mass index (BMI), but their role in determination of BMI changes after combined dietary/physical ac tivity intervention is unclear. We have analyzed 107 unrelated overweight non-diabetic Czech females (BMI over 27.5 kg/m2 , age 49.2±12.3 years). FTO variants rs17817449 (first intron) and rs17818902 (third intron) were genotyped. The life style mo dification program (10 weeks) consisted of an age- matched reduction of energy intake and exercise program (aerobic exercise 4 times a week, 60 min each). The mean BMI before intervention was 32.8±4.2 kg/m2 and the mean achieved weight loss was 4.8±3.5 kg (5.3±3.5 %, max. -15.5 kg, min. +2.0 kg, p<0. 01). No significant association between BMI decrease and FTO variants was found. Also waist-to-hip ratio, body composition (body fat, water, active tissue), lipid parameters (total, LDL and HDL cholesterol, triglycerides) glucose and hsCRP change s were independent on FTO variants. FTO variants rs17817449 and rs17818902 are not associated with BMI changes after combined short time dietary/physical activity intervention in overweight females., D. Dlouhá ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:1

Harvested from:

CDK

Metadata only:

false