Lectins in snail-trematode immune interactions: a review

Title:

Lectins in snail-trematode immune interactions: a review

Creator:

Horák, Petr and van der Knapp, Wil P. W.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fca9c4b6-7985-4099-b7d3-a16d6c51d6f2
uuid:fca9c4b6-7985-4099-b7d3-a16d6c51d6f2
urnnbn:urn:nbn:cz:aba007-000dnf

Subject:

lectin, agglutinin, carbohydrate, trematode, schistosome, snail, immunity, and haemocyte

Type:

model:internalpart and TEXT

Format:

print

Description:

Lectins as carbohydrate recognition proteins other than enzymes or immunoglobulins play important roles in living systems, e.g., in celi celi recognition. They are considered to be involved in snail-trematode immune interactions, i.e., in a system where antibodies are lacking and lectins might at least partially substitute immunoglobulin functions. From the snail side, lectins can be located on haemocyte surfaces as receptors for foreignness and they can be found freely in plasma. The latter can function as agglutinins/opsonins helping in the recognition of parasites by haemocytes. They may also link immune cells and pathogens by recognition of surface carbohydrates on both. Lectins of parasite origin could also be involved in snail-trematode interactions. They might function as trematode surface receptors for snail glycoconjugates in parasite masking strategies. Functions other than the involvement in the snail's immune response or the parasite’s evasion strategies might be fulfilled by lectins as well. Among these may be host-finding, penetration, orientation in the host, nutrition. It cannot be omitted that lectin-saccharide reactions represent only a part of the snail-trematode interactions and thus, results obtained from lectin experiments are a rough simplification of the actual, very complicated situation. An array of immune and other reactions comprised of yet unknown bioactive molecules certainly exists in snails and, on the other hand, trematode mechanisms to escape or otherwise interact with these, might be involved at the same time. But we can certainly conclude that a more complete view of the complex snail-trematode interactions also necessitates a more profound knowledge of the identity and functioning of lectins and their ligands, in host and parasite.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

161-172 and 3-14

Source:

Folia parasitologica | 1997 Volume:44 | Number:3

Harvested from:

CDK

Metadata only:

false