Selective antioxidant enzymes during ischemia / reperfusion in myocardial infarction

Title:

Selective antioxidant enzymes during ischemia / reperfusion in myocardial infarction

Creator:

Mužáková, V., Roman Kanďár, Pavel Vojtíšek, Jiří Skalický, and Zuzana Červinková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:faa16510-ca5a-40ce-b6c7-f9698126bc26
uuid:faa16510-ca5a-40ce-b6c7-f9698126bc26
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, infarkt myokardu, oxidační stres, myocardial infarction, oxidative stress, superoxide dismutase, glutathione peroxidase, malondialdehyde, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The study of ischemia/reperfusion injury included 25 patients in the acute phase of myocardial infarction (19 perfused, 6 remained non-reperfused as evaluated according to the time course of creatine kinase and CK-MB isoenzyme activity) and a control group (21 blood donors). Plasma level of malondialdehyde was followed as a marker of oxidative stress. Shortly after reperfusion (within 90 min), a transient increase of malondialdehyde concentration was detected. The return to the baseline level was achieved 6 h after the onset of therapy. The activity of a free radical scavenger enzyme, plasma glutathione peroxidase (GPx), reached its maximum 90 min after the onset of treatment and returned to the initial value after 18 h. The specificity of the GPx response was confirmed by comparing with both non-reperfused patients and the control group, where no significant increase was detected. The erythrocyte Cu,Zn-superoxide dismutase (SOD) did not exhibit significant changes during the interval studied in perfused patients, probably due to the stability of erythrocyte metabolism. In non-reperfused patients, a decrease of SOD was found during prolonged hypoxia. These results help to elucidate the mechanisms of fast activation of plasma antioxidant system during the reperfusion after myocardial infarction., V. Mužáková, R. Kanďár, P. Vojtíšek, J. Skalický, Z. Červinková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:3

Harvested from:

CDK

Metadata only:

false