Baroreflex control of heart rate in young and adult salt hypertensive inbred dahl rats

Title:

Baroreflex control of heart rate in young and adult salt hypertensive inbred dahl rats

Creator:

Jan Nedvídek and Josef Zicha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f3d381c9-2863-4dcd-b13c-ad9bfc58b9b2
uuid:f3d381c9-2863-4dcd-b13c-ad9bfc58b9b2
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, srdeční rytmus, krevní tlak, stárnutí, heart rate, blood pressure, aging, baroreflex sensitivity, salt intake, phenylephrine, inbred Dahl rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Baroreflex control of heart rate was studied in inbred salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats that were subjected to chronic dietary sodium chloride loading (for 4 weeks) either in youth or only in adulthood, i.e. from the age of 4 or 12 weeks. Using phenylephrine administration to pentobarbital-anesthetized male rats we have demonstrated the decreased baroreflex sensitivity (lower slope for reflex bradycardia) in young prehypertensive SS/Jr rats fed a low-salt diet as compared to age-matched SR/Jr animals. High salt intake further suppressed baroreflex sensitivity in young SS/Jr but not in SR/Jr rats. Baroreflex sensitivity decreased with age in SR/Jr rats, whereas it increased in SS/Jr rats fed a low-salt diet. Thus at the age of 16 weeks baroreflex sensitivity was much higher in SS/Jr than in SR/Jr animals. High salt intake lowered baroreflex sensitivity even in adult SS/Jr rats without affecting it in adult SR/Jr rats. Nevertheless, baroreflex sensitivity was significantly lower in young SS/Jr rats with a severe salt hypertension than in adult ones with a moderate blood pressure elevation. It is concluded that the alterations of baroreflex sensitivity in young inbred SS/Jr rats (including the response to high salt intake) are similar to those described earlier for outbred salt-sensitive Dahl rats. We have, however, disclosed contrasting age-dependent changes of baroreflex sensitivity in both inbred substrains of Dahl rats., J. Nedvídek, J. Zicha., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:3

Harvested from:

CDK

Metadata only:

false