Increased serum levels of C21 steroids in female patients with multiple sclerosis

Title:

Increased serum levels of C21 steroids in female patients with multiple sclerosis

Creator:

Radmila Kancheva, Luboslav Stárka, Lyudmila Kantcheva, Hill, M., Veliková, M., and Eva Havrdová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f1e2ccde-e1ee-4604-8247-d73768b1bcd1
uuid:f1e2ccde-e1ee-4604-8247-d73768b1bcd1
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, roztroušená skleróza, ženy, multiple sclerosis, women, neurosteroids, GC-MS, multivariate regression, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Multiple sclerosis (MS) is one of the most common neurological diseases. This neurodegenerative autoimmune disease manifests as inflammatory and demyelinating impairment of the central nervous system (CNS). Although some studies demonstrated associations between altered steroidogenesis and pathophysiology of MS as well as the importance of steroids in the pathophysiology of MS, the knowledge concerning the steroid metabolome in female patients is limited. Hence, 51 steroids and steroid polar conjugates were measured in the serum of 12 women with MS, untreated with steroids and 6 agecorresponding female controls with the use of gas chromatography - mass spectrometry (GC-MS). The data were processed using age adjusted ANCOVA, receiver operating characteristics (ROC) analysis and orthogonal projections to latent structures (OPLS). Our data show higher levels of circulating C21 steroids including steroid modulators of ionotropic type A γ-aminobutyric acid (GABA A) receptors and glutamate receptors. Furthermore, the levels of GABAergic androsterone and 5-androsten-3β,7α,17β-triol were also higher in the female MS patients. In conclusion, the data demonstrate higher levels of circulating C21 steroids and their polar conjugates and some bioactive C19 steroids in women with MS, which may influence neuronal activity and affect the balance between neuroprotection and excitotoxicity., R. Kanceva, L. Stárka, L. Kancheva, M. Hill, M. Veliková, E. Havrdová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false