Is the amount of coronary perivascular fat related to atherosclerosis?

Title:

Is the amount of coronary perivascular fat related to atherosclerosis?

Creator:

Ivana K. Lesná, Zbyněk Tonar, Ivan Málek, Jana Malušková, Lukáš Nedorost, Jan Pirk, Jan Piťha, Věra Lánská, and Rudolf Poledne

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f0a749a5-b868-4c8c-a831-442e51e96e92
uuid:f0a749a5-b868-4c8c-a831-442e51e96e92
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, věnčité tepny, ateroskleróza, coronary arteries, atherosclerosis, perivascular fat, macrophages, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Interesting and stimulating data about the effect of the perivascular adipose tissue size on atherogenesis are based mainly on CT findings. We studied this topic by directly analyzing perivascular adipose tissue in explanted hearts from patients undergoing transplantation. Ninety -six consecutive patients were included, including 58 with atherosclerotic coronary heart disease (CHD) and 38 with dilation cardiomyo pathy (DCMP). The area of perivascular fat, area of the coronary artery wall, and ratio of CD68 -positive macrophages within the perivascular fat and within the vascular wall were quantified by immunohistochemistry. There was no significant difference in th e perivascular adipose tissue size between the two groups. Nevertheless, there was a significantly higher number of macrophages in the coronary arterial wall of CHD patients. In addition, we found a close relationship between the ratio of macrophages in th e arterial wall and adjacent perivascular adipose tissue in the CHD group, but not in the DCMP group . According to our data interaction between macrophages in the arterial wall and macrophages in surrounding adipose tissue could be more important mechanism of atherogenesis than the size of this tissue itself., I. Kralova Lesna, Z. Tonar, I. Malek, J. Maluskova, L. Nedorost, J. Pirk, J. Pitha, V. Lanska, R. Poledne., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false