Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease

Title:

Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease

Creator:

Zhao, L., He, L. X., Huang, S. N., Gong, L. J., Li, L., Lv, Y. Y., and Qian, Z. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ec47c2d6-40b9-4ddc-ae38-fccd4cb20eac
uuid:ec47c2d6-40b9-4ddc-ae38-fccd4cb20eac
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, Parkinsonova nemoc, dopamin, Parkinson's disease, dopamine, vibration training (VT), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), substantia nigra, striatum, tyrosine hydroxylase (TH), brain-derived neurotrophic factor (BDNF), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

It is unknown whether the longer duration of vibration training (VT) has a beneficial effect on Parkinson's disease (PD). And also, the mechanisms underlying the reported sensorimotorimprovement in PD induced by short-duration of VT has not been determined. Here, we investigated the effects of longer duration (4 weeks) of low amplitude vibration (LAV) training on the numbers of dopaminergic neurons in the substantia nigra by immunostaining and the levels of dopamine (DA) and brainderived neurotrophic factor (BDNF) in the striatum by HPLC and ELISA in the chronic MPTP lesion mouse. We demonstrated for the first time that the longer duration of VT could significantly increase the numbers of nigrostriatal DA neurons and the contents of striatal DA and BDNF in the MPTP mice. Our findings implied that longer duration of VT could protect dopaminergic neurons from the MPTP-induced damage probably by upregulating BDNF and also provided evidence for the beneficial effect of longer duration of VT on PD at the cellular and molecular level., L. Zhao, L. X. He, S. N. Huang, L. J. Gong, L. Li, Y. Y. Lv, Z. M. Qian., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:5

Harvested from:

CDK

Metadata only:

false