Impaired vitamin D sensitivity

Title:

Impaired vitamin D sensitivity

Creator:

Ludmila Máčová, Marie Bičíková, and Richard Hampl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ea5f8aca-7c03-4516-83b2-9251a7821143
uuid:ea5f8aca-7c03-4516-83b2-9251a7821143
issn:0862-8408

Subject:

vitamin D, molekulární mechanika, molecular mechanics, resistance, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Findings of extra-skeletal effects of vitamin D and learning of the molecular mechanisms used by its biologically active metabolite calcitriol revealed other ways leading to its impaired sensitivity. Calcitriol takes advantage of both genomic and non-genomic mechanisms through its binding to vitamin D receptor, located not only in the cell nuclei but also in a perinuclear space. On the genomic level the complex of calcitriol bound to VDR binds to the DNA responsive elements of the controlled gene in concert with another nuclear receptor, retinoid X receptor, and expression of the VDR itself is controlled by its own ligand. These elements were found not only in the promotor region, but are scattered over the gene DNA. The gene expression includes a number of nuclear transcription factors which interact with the responsive elements and with each other and learning how they operate would further contribute to revealing causes of the impaired vitamin D sensitivity. Finally, the examples of major disorders are provided, associated with impairment of the vitamin D function and its receptor., L. Máčová, M. Bičíková, R. Hampl., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false