Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients

Title:

Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients

Creator:

Vilém Danzig, Míková, B., Petr Kuchynka, Hana Benáková, Tomáš Zima, Otomar Kittnar, Jan Škrha, Aleš Linhart, and Marta Kalousová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e56754df-8f4b-47bc-8680-6f400d4e981d
uuid:e56754df-8f4b-47bc-8680-6f400d4e981d

Subject:

Fyziologie člověka a srovnávací fyziologie, věnčité tepny, záněty, metaloproteiny, natriuretické peptidy, oxidační stres, coronary arteries, inflammations, metalloproteins, natriuretic peptides, oxidative stress, coronary artery disease, metalloproteinases, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

As traditional risk factors are unable to fully explain the pathogenesis of coronary artery disease (CAD), novel mechanisms became a target of many investigations. Our aim was to study the response of selected markers to physical exercise. High-sensitive C-reactive protein (hs-CRP), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), advanced oxidation protein products (AOPP), soluble receptor for advanced glycation end-products (sRAGE), pregnancy-associated plasma protein A (PAPP-A), E-selectin, vascular endothelial growth factor (VEGF) and B-type natriuretic peptide (BNP) levels were measured in serum of 21 CAD patients and in 22 healthy controls at rest and after exercise bicycle stress test performed up to the maximal tolerated effort. At rest, hs-CRP, AOPP, MMP-9 and BNP were significantly elevated in the CAD patients as compared with controls. In contrast, P-selectin was significantly lower in CAD patients and a tendency to lower levels of sRAGE was noted. After exercise MMP-9 and BNP, increased significantly in both groups. In conclusions, CAD patients have elevated hs-CRP, AOPP, MMP-9 and BNP - novel markers related to cardiovascular risk or left ventricular overload. MMP-9 and BNP increase significantly with exercise in both healthy individuals and CAD patients., V. Danzig ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:3

Harvested from:

CDK

Metadata only:

false