The effects of acute hypoxia on tissue oxygenation and circulating alarmins in healthy adults

Title:

The effects of acute hypoxia on tissue oxygenation and circulating alarmins in healthy adults

Creator:

Boos, C. J., Lamb, C. M. , Midwinter, M., Mellor, A., Woods, D. R., Howley, M., Stansfield, T., Foster, M. , and O’Hara, J. P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e4a6eb2e-dbcc-47a0-9a6f-cc670fbcd44a
uuid:e4a6eb2e-dbcc-47a0-9a6f-cc670fbcd44a

Subject:

acute hypoxia, normobaric, alarmins, sRAGE, and exercise

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

The binding of high-mobility group box-1 (HMGB-1) to the membrane receptor for advanced glycation end-products (mRAGE) is a key early mediator of non-infectious inflammation and its triggers include ischaemia/hypoxia. The effects of acute hypoxia on soluble RAGE (sRAGE) are unknown. Fourteen healthy adults (50 % women; 26.6±3.8 years) were assessed at baseline normoxia (T0), followed by four time-points (T90, 95, 100 and 180 min) over three hours of continuous normobaric hypoxia (NH, 4,450 m equivalent) and again 60 min after return to normoxia (T240). A 5-min exercise step test was performed during NH at T90. Plasma concentrations of HMGB-1, sRAGE VCAM-1, ICAM-1, VEGF IL-8 and IL-13 were measured using venous blood. Arterial and tissue oxygen saturations were measured using pulse oximetry (SpO2) and near-infrared spectroscopy (StO2), respectively. NH led to a significant reduction in SpO2, StO2, sRAGE and VEGF, which was compounded by exercise, before increasing to baseline values with normoxic restoration (T240). NH-exercise led to a paired increase in HMGB-1. sRAGE inversely correlated with HMGB-1 (r=-0.32; p=0.006), heart rate (r=-0.43; p=0.004) but was not linked to SpO2 or StO2. In conclusion, short-term NH leads to a fall in sRAGE and VEGF concentrations with a transient rise post NH-exercise in HMGB-1.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:6

Harvested from:

CDK

Metadata only:

false