Buccal respiratory chain complexes I and IV quantities in Huntington´s disease patients

Title:

Buccal respiratory chain complexes I and IV quantities in Huntington´s disease patients

Creator:

Dušek, P., Rodinová, M., Lišková, I., Klempíř, J., Zeman, J., Roth, J., and Hansíková, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d861e2e6-76fd-4a5c-b98a-ea725fd6e084
uuid:d861e2e6-76fd-4a5c-b98a-ea725fd6e084

Subject:

Huntingon´s disease, mitochondria, buccal epithelium, OXPHOS, and dipstick immunoassay

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Alterations in mitochondrial parameters are an important hallmark of Huntington’s disease (HD). The ubiquitous expression of mutant huntingtin raises the prospect that mitochondrial disturbances can also be detected and monitored through buccal epithelial cells. In a group of 34 patients with Huntington’s disease and a group of 22 age-related healthy volunteers, respiratory complex I and IV protein quantities in buccal epithelial cells were measured using the dipstick immunocapture assay. The protein quantity of respiratory complex I correlates with age (r = 0.427, P = 0.026, FWE-P = 0.156) in the patient group, but not in the group of healthy subjects. Our non-invasive approach allows us to obtain valuable information for the studies of mitochondrial biochemical parameters in patients with neurodegenerative diseases and could also be useful in epidemiological studies. and Corresponding author: Hana Hansíková

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

[31]-34

Source:

Folia biologica | 2018 Volume:64 | Number:1

Harvested from:

CDK

Metadata only:

false