Activation of HPA axis and remodeling of body chemical composition in response to an intense and exhaustive exercise in C57BL/6 mice

Title:

Activation of HPA axis and remodeling of body chemical composition in response to an intense and exhaustive exercise in C57BL/6 mice

Creator:

Rosa, E. F., Alves, G. A., Luz, J., Silva, S. M. A., Suchecki, D., Pesquero, J. B., Aboulafia, J., and Nouailhetas, V. L. A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cd212f34-4647-48c1-b6e0-2ca1ad5d02c1
uuid:cd212f34-4647-48c1-b6e0-2ca1ad5d02c1
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, tělesné složení, nadledviny, brzlík, body composition, adrenal glands, thymus, intense exercise, HPA axis, gastrocnemius muscle, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice., E. F. Rosa, G. A. Alves, J. Luz, S. M. A. Silva, D. Suchecki, J. B. Pesquero, J. Aboulafia, V. L. A. Nouailhetas., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:5

Harvested from:

CDK

Metadata only:

false