Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period

Title:

Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period

Creator:

Rezková, Markéta and Jan Kopecký

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cb39a05e-ba83-402b-b185-b7a03b9597d0
uuid:cb39a05e-ba83-402b-b185-b7a03b9597d0
issn:1803-6465
doi:10.14411/fp.2017.032

Subject:

cytokiny, cytokines, ixodid ticks, immunomodulation, 2, and 59

Type:

model:article and TEXT

Format:

print, počítač, and online zdroj

Description:

Tumour necrosis factor (TNF) plays a central role in the inflammatory process. In the skin, it contributes to immune containment of tick-transmitted pathogens like Borrelia burgdorferi. In the saliva of some tick species, active compounds are present that inhibit detection of TNF in specific ELISA. We compared the presence of anti-TNF activity in saliva or salivary gland extract from 11 tick species from the family Ixodidae and demonstrated it in genera Ixodes Latreille, 1795 and Haemaphysalis Koch, 1844. Analysis of anti-TNF activity in Ixodes ricinus (Linnaeus, 1758) saliva during the feeding period showed that it is present in the late, rapid phase of engorgement. Significance of anti-TNF activity for tick feeding and transmission of tick-borne pathogens is discussed., Markéta Rezková, Jan Kopecký., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

1-5

Source:

Folia parasitologica | 2017 Volume:64 | Number:1

Harvested from:

CDK

Metadata only:

false