Effect of methamphetamine on cognitive functions of adult female rats prenatally exposed to the same drug

Title:

Effect of methamphetamine on cognitive functions of adult female rats prenatally exposed to the same drug

Creator:

Macúchová, E., Kateryna Nohejlová, and Romana Šlamberová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:cb24c61e-e371-4bcc-90c3-4a87b764ea27
uuid:cb24c61e-e371-4bcc-90c3-4a87b764ea27

Subject:

Fyziologie člověka a srovnávací fyziologie, pervitin, paměť, methamphetamine, memory, Morris water maze, spatial learning, sensitization, estrous cycle, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of this study was to inve stigate the effect of prenatal methamphetamine (MA) exposure and application of the same drug in adulthood on cognitive functions of adult female rats. Animals were prenatally exposed to MA (5 mg/kg) or saline (control group). The cognitive function was tested as ability of spatial learning in the Morris Water Maze (MWM). Each day of the experiment animals received an injection of MA (1 mg/kg) or saline. Our results demonstrated that prenatal MA exposure did not affect the latency to reach the hidden platform or the distance traveled during the Place Navigation Test; however, the speed of swimming was increased in prenatally MA-exposed rats compared to controls regardless of the treatment in adulthood. MA treatment in adulthood increased the latency and distance when compared to controls regardless of the prenatal exposure. Neither prenatal exposure, nor tr eatment in adulthood affected memory retrieval. As far as the estrous cycle is concerned, our results showed that prenatally MA-exposed females in proestrus/estrus swam faster than females in diestrus. This effect of estrous cycle was not apparent in control females. In conclusion, our results indicate that postnatal, but not prenatal exposure to MA affects learning of adult female rats., E. Macúchová, K. Nohejlová-Deykun, R. Šlamberová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false