Spontaneous quantal and non-quantal release of acetylcholine at mouse endplate during onset of hypoxia

Title:

Spontaneous quantal and non-quantal release of acetylcholine at mouse endplate during onset of hypoxia

Creator:

Bukharaeva, E.A., Salakhutdinov, R.I., Vyskočil, F., and Nikolsky , E.E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c7728a4a-9f7b-43ad-9887-5e1ce9dbe53f
uuid:c7728a4a-9f7b-43ad-9887-5e1ce9dbe53f

Subject:

Miniature potential, Acetylcholine, Quantal release, Non-quantal release, and Hypoxia

Type:

article, model:article, and TEXT

Description:

At 20oC, both quantal and non-quantal spontaneous acetylcholine release (expressed as miniature endplate potential frequency [f-MEPPs] and the H-effect, respectively) increased during the first 30 min of hypoxia in solution with normal extracellular calcium ([Ca2+]o = 2.0 mM). The hypoxia-induced tenfold increase of the f-MEPPs was virtually absent in low calcium solution ([Ca2+]o = 0.4 mM) whereas there was still a significant increment of non-quantal release. This indicates that each of these two processes of acetylcholine release is influenced by mechanisms with different oxygen sensitivity. The rise of f-MEPPs during the onset of hypoxia apparently requires Ca2+ entry into the nerve terminal, whereas the non-quantal release can be increased by another factors such as a lower level of ATP.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:2

Harvested from:

CDK

Metadata only:

false