A subpressor dose of angiotensin II elevates blood pressure in a normotensive rat model by oxidative stress

Title:

A subpressor dose of angiotensin II elevates blood pressure in a normotensive rat model by oxidative stress

Creator:

Govender, M. M. and Nadar, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c70fccde-08fe-4f1b-9382-eff3bcf60700
uuid:c70fccde-08fe-4f1b-9382-eff3bcf60700
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxidační stres, hypertenze, oxidative stress, hypertension, angiotensin II, subpressor, superoxide radical, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Oxidative stress is an imbalance between free radicals and antioxidants, and is an important etiological factor in the development of hypertension. Recent experimental evidence suggests that subpressor doses of angiotensin II elevate oxidative stress and blood pressure. We aimed to investigate the oxidative stress related mechanism by which a subpressor dose of angiotensin II induces hypertension in a normotensive rat model. Normotensive male Wistar rats were infused with a subpressor dose of angiotensin II for 28 days. The control group was sham operated and infused with saline only. Plasma angiotensin II and H2O2 levels, whole-blood glutathione peroxidase, and AT-1a, Cu/Zn SOD, and p22phox mRNA expression in the aorta was assessed. Systolic and diastolic blood pressures were elevated in the experimental group. There was no change in angiotensin II levels, but a significant increase in AT-1a mRNA expression was found in the experimental group. mRNA expression of p22phox was increased significantly and Cu/Zn SOD decreased significantly in the experimental group. There was no significant change to the H2O2 and GPx levels. Angiotensin II manipulates the free radical-antioxidant balance in the vasculature by selectively increasing O2 - production and decreasing SOD activity and causes an oxidative stress induced elevation in blood pressure in the Wistar rat., M. M. Govender, A. Nadar., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:2

Harvested from:

CDK

Metadata only:

false