Detection of cervical lymph node micrometastases in patients with squamous cell carcinoma of the oral cavity, pharynx and larynx

Title:

Detection of cervical lymph node micrometastases in patients with squamous cell carcinoma of the oral cavity, pharynx and larynx
Detection of cervical lymph node micrometastases in patients with squamous cell carcinoma of the oral cavity, pharynx and larynx

Creator:

Čelakovský, Petr, Kalfeřt, David, Smatanová, Katarína, Chrobok, Viktor, and Laco, Josef

Contributor:

Čelakovský, Petr , 1966-, Kalfeřt, David, Smatanová, Katarína, Chrobok, Viktor , 1964-, and Laco, Josef

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15040063-053da7c1-d4d7-462b-9ca3-6141b3105385
uuid:bmc15040063-053da7c1-d4d7-462b-9ca3-6141b3105385
local:bmc15040063
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2015.95
local: bmc15040063

Subject:

spinocelulární karcinom--patologie--chirurgie, ženské pohlaví, lidé, nádory hrtanu--patologie--chirurgie, lymfadenektomie--metody, mužské pohlaví, lidé středního věku, nádory úst--patologie--chirurgie, disekce krku--metody, mikrometastázy--diagnóza--patologie, staging nádorů, péče o pacienty - plánování, nádory hltanu--patologie--chirurgie, prediktivní hodnota testů, prognóza, prospektivní studie, and reprodukovatelnost výsledků

Type:

model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT

Format:

print, text, and regular print

Description:

BACKGROUND: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). PATIENTS AND METHODS: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42-73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. RESULTS: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. CONCLUSION: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases. and P. Čelakovský, D. Kalfeřt, K. Smatanová, V. Chrobok, J. Laco

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

Česká republika

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2015 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2015