Cellular responses to egg-oil (charismon©)

Title:

Cellular responses to egg-oil (charismon©)
Cellular responses to egg-oil (charismon©)

Creator:

Bereiter-Hahn, Jürgen, Bernd, August, Beschmann, Heike, Eberle, Irina, Kippenberger, Stefan, Rossberg, Maila, Strecker, Valentina, and Zöller, Nadja

Contributor:

Bereiter-Hahn, Jürgen, Bernd, August, Beschmann, Heike, Eberle, Irina, Kippenberger, Stefan, Rossberg, Maila, Strecker, Valentina, and Zöller, Nadja

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14074053-3965bb35-2a6d-496b-833c-04155893820d
uuid:bmc14074053-3965bb35-2a6d-496b-833c-04155893820d
local:bmc14074053
https://www.lfhk.cuni.cz/Faculty/Publications/Acta-Medica/Archive/
doi: 10.14712/18059694.2014.38
local: bmc14074053

Subject:

zvířata, apoptóza--účinky léků, buněčné linie, pohyb buněk--účinky léků, proliferace buněk--účinky léků, buněčné dýchání--účinky léků, buňky kultivované, kur domácí, cytokiny--metabolismus, vejce, epidermis--cytologie, lidé, membránový potenciál mitochondrií--účinky léků, oleje--chemie--farmakologie, reaktivní formy kyslíku--metabolismus, sluneční spáleniny--farmakoterapie, and hojení ran--účinky léků

Type:

model:article, article, Text, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

Egg-oil (Charismon©) is known for its beneficial action in wound healing and other skin irritancies and its antibacterial activity. The physiological basis for these actions has been investigated using cells in culture: HaCaT-cells (immortalized human keratinocytes), human endothelial cells in culture (HUVEC), peripheral blood mononuclear lymphocytes (PBML) and a full thickness human skin model (FTSM). Emphasis was on the influence of egg-oil on cell migration and IL-8 production in HaCaT cells, respiration, mitochondrial membrane potential, reactive oxygen (ROS)production and proliferation in HUVEC and HaCaT cells, cytokine and interleukin production in PBML and UV-light induced damage of FTSM. IL-8 production by HaCaT cells is stimulated by egg-oil whilst in phythemagglutinin-activated PBMLs production of the interleukins IL-2, IL-6, IL-10 and IFN-γ and TFN-α is reduced. ROS-production after H₂O₂ stimulation first is enhanced but later on reduced. Respiration becomes activated due to partial uncoupling of the mitochondrial respiratory chain and proliferation of HaCaT and HUVEC is reduced. Recovery of human epidermis cells in FTSM after UV-irradiation is strongly supported by egg-oil. These results support the view that egg-oil acts through reduction of inflammatory processes and ROS production. Both these processes are equally important in cellular aging as in healing of chronic wounds. and J. Bereiter-Hahn, A. Bernd, H. Beschmann, I. Eberle, S. Kippenberger, M. Rossberg, V. Strecker, N. Zöller

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Kralove) Universitas Carolina, Facultas Medica Hradec Kralove--MED00010947

Source:

Acta medica (Hradec Králové) | 2014 Volume:57 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2014