Determination of Ketoconazole in tablets by using three different methods

Title:

Determination of Ketoconazole in tablets by using three different methods
Determination of Ketoconazole in tablets by using three different methods

Creator:

Gjorgjeska, Biljana

Contributor:

Gjorgjeska, Biljana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc14046147-601a7976-5bcb-415c-b262-14df58c658ee
uuid:bmc14046147-601a7976-5bcb-415c-b262-14df58c658ee
local:bmc14046147
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
local: bmc14046147

Subject:

senzitivita a specificita, chromatografie vysokotlaká kapalinová, 14-alfa-demethylasa - inhibitory--chemie, antifungální látky--chemie, lékové formy, spektrofotometrie ultrafialová, potenciometrie, řízení kvality, lidé, and Oromycosal®

Type:

model:article, article, Text, statistics, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Ketoconazole has been widely used as an antifungal drug that is formulated as tablets, cream and overthecounter ketoconazole shampoo. The aim of this research was to study and to standardize an ultraviolet spectrophotometric (UVS) method, potentiometric and a high performance liquid chromatographic (HPLC) method for the determination of ketoconazole in commercially available Oromycosal® tablets. These three methods were compared and discussed with respect to their sensitivity, selectivity and readyapplicability in routine analytical work. Absorption spectra and spectrophotometric determinations were carried out on the UVS spectrophotometer. Investigated concentrations were in range from 0.003 to 0.02mg?dm3. The absorbance was measured at 224 nm. In potentiometric titrations glass and saturated (KCl) calomel electrode were used. HPLC analyses of ketoconazole were carried in the presence of econazole as internal standard. It can be concluded that the described methods are simple, fast and reliable for determination of ketoconazole in pharmaceutical preparations. The preparation of the samples is easy, the excipients do not interfere in the methods, so they can be used in routine quality control analysis., Biljana Gjorgjeska, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2012 Volume:2012 | Number:4

Harvested from:

CDK

Metadata only:

false

Date:

2012