Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma

Title:

Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma
Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma

Creator:

Beránek, Martin, Drastíková, Monika, Paulíková, Simona, Sirák, Igor, Vošmik, Milan, and Petera, Jiří

Contributor:

Beránek, Martin , 1968-, Drastíková, Monika, Paulíková, Simona, Sirák, Igor, Vošmik, Milan , 1972-, and Petera, Jiří , 1959-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12000518-d756d7bc-515b-410f-9109-705dc27d3ab1
uuid:bmc12000518-d756d7bc-515b-410f-9109-705dc27d3ab1
local:bmc12000518
http://www.lfhk.cuni.cz/Data/files/Casopisy/2011/2011_111.pdf
local: bmc12000518

Subject:

nádory děložního čípku--radioterapie, vztah dávky záření a odpovědi, tolerance záření--genetika, genotypizační techniky--využití, proteiny vážící DNA--genetika--metabolismus, protein-serin-threoninkinasy--genetika--metabolismus, mutace--genetika, lidé, ženské pohlaví, skupina pocházející z evropského kontinentu--genetika, and financování organizované

Type:

model:article, article, Text, and TEXT

Format:

braille, text, and regular print

Description:

Clinical oncologists have been focusing their efforts on attempting to define risk groups of patients with unusual biological reactions to the recommended therapy regimens using molecular biology techniques. The aims of our study were: (i) to find a design and validate a method for fast and reliable analysis of the D1853N (5557G>A) genetic polymorphism in the ATM (ataxia-telangiectasia mutated) gene; (ii) to use side-directed mutagenesis to generate ATM 5557A-positive DNA (reference ATM5557A DNA); and (iii) to analyze a group of patients suffering from cervical carcinoma with adverse responses to radiotherapy. The 5557A variant was found in three of twenty women (15%). Our data show that the prevalence of the 5557A allelic variant in cervical cancer subjects with adverse responses after irradiation probably does not differ from the prevalence common in Caucasians. A larger population study should confirm these preliminary results., Martin Beránek, Monika Drastíková, Simona Paulíková, Igor Sirák, Milan Vošmik, Jiří Petera, and Literatura 31

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2011 Volume:54 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2011