Wnt/β-catenin signaling: a promising new target for fibrosis diseases

Title:

Wnt/β-catenin signaling: a promising new target for fibrosis diseases

Creator:

Guo, Y., Xiao, L., Sun, L., and Liu, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bef1eb35-b86a-42ab-8b0d-b6e3851c2f17
uuid:bef1eb35-b86a-42ab-8b0d-b6e3851c2f17

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, wnt, β-catenin, fibrosis, TGF-β, microRNA, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Wnt/β-catenin signaling is involved in virtually every aspect of embryonic development and also controls homeostatic selfrenewal in a number of adult tissues. Recently, emerging evidence from researches of organ fibrosis suggest that sustained Wnt/β-catenin pathway reactivation is linked to the pathogenesis of fibrotic disorders. Here we focus on Wnt/β-catenin-related pathogenic effects in different organs, such as lung fibrosis, liver fibrosis, skin fibrosis and renal fibrosis. Additionally, Wnt/β- catenin signaling works in a combinatorial manner with TGF-β signaling in the process of fibrosis, and TGF-β signaling can induce expression of Wnt/β-catenin superfamily members and vice versa. Moreover, network analysis, based on pathway databases, revealed that key factors in the Wnt pathway were targeted by some differentially expressed microRNAs detected in fibrosis diseases. These findings demonstrated the crosstalks between Wnt/β-catenin pathway and TGF-β signalings, and microRNAs, highlighting the role of Wnts in organ fibrogenesis. Most importantly, nowadays there is a variety of Wnt pathway inhibitors which give us the potential therapeutic feasibility, modulation of the Wnt pathway may, therefore, present as a suitable and promising therapeutic strategy in the future., Y. Guo ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:4

Harvested from:

CDK

Metadata only:

false