Citalopram Inhibits L-type Calcium Channel Current in Rat Cardiomyocytes in Culture

Title:

Citalopram Inhibits L-type Calcium Channel Current in Rat Cardiomyocytes in Culture

Creator:

Hamplová-Peichlová, J., Jan Krůšek, Ivo Paclt, Jaroslav Slavíček, Lisá, V., and František Vyskočil

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bd0b650a-b35a-435e-ae72-90dcbf479480
uuid:bd0b650a-b35a-435e-ae72-90dcbf479480
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Citalopram, Amitriptyline, L-type calcium channel current, Whole cell configuration patch-clamp, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Selective serotonine reuptake inhibitors (SSRI) are believed to be less dangerous in the treatment of depressive disorder in comparison with tricyclic antidepressants (TCA) due to their relative lack of cardiotoxicity. Thus, we investigated the effect of citalopram (SSRI) on membrane electrophysiology in rat cardiomyocytes in tissue culture. The results were compared with those from amitriptyline (TCA). The whole-cell configuration patch-clamp technique was used. Both citalopram and amitriptyline exhibited the concentration-dependent inhibition of the L-type calcium channel current (ICa). Citalopram in concentrations of 3 mM and 10 mM inhibited peak calcium current by 2.7 % and 8 %, respectively. We demonstrated the same potency of citalopram and amitriptyline to inhibit ICa. These observations led us to conclude that citalopram and amitriptyline are drugs, which exhibit a similar potency for causing concentration-dependent inhibition of ICa., J. Hamplová-Peichlová, J. Krůšek, I. Paclt, J. Slavíček, V. Lisá, F. Vyskočil., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:3

Harvested from:

CDK

Metadata only:

false