The effect of aortic coarctation surgical repair on QTc and JTc dispersion in severe aortic coarctation newborns: a short-term folow-up study

Title:

The effect of aortic coarctation surgical repair on QTc and JTc dispersion in severe aortic coarctation newborns: a short-term folow-up study

Creator:

Nigro, G., Russo, V., Papa, A. A., Cioppa, N. D., Scarpati, C., Palladino, T., Corcione, A., Sarubbi, B., Caianiello, G., and Russo, M. G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bcb884a0-1411-48f6-8887-905aa9044abe
uuid:bcb884a0-1411-48f6-8887-905aa9044abe

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, QT dispersion, JT dispersion, aortic coarctation, repolarization, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Sudden death is a possible occurrence for newborns younger than 1 year with severe aortic coarctation (CoA) before surgical correction. In our previous study, we showed a significant increase of QTc-D and JTc-D in newborns with isolated severe aortic coarctation, electrocardiog raphic parameters that clinical and experimental studies have suggested could reflect the physiological variability of regional and ventricular repolarization and could provide a substrate for life-threatening ventricular arrhythmias. The aim of the current study was to evaluate the effect of surgical repair of CoA on QTc-d, JTc-d in severe aortic coarctation newborns with no associated congenital cardiac malformations. The study included 30 newborns (18M; 70±12 h old) affected by severe congenit al aortic coarct ation, without associated cardiac malformation s. All newborns underwent to classic extended end-to-end repair. Echocardiographic and electrocardiographic measurements were performed in each patient 24 h before and 24 h afte r the interventional procedure and at the end of the follow-up period, 1 month after the surgical correction. All patients at baseline, 24 h and one month after CoA surgical repair did not significantly differ in terms of heart rate, weight, height, and echocardiographic parameters. There were no statistically significant differences in QTc-D (111.7±47.4 vs 111.9±63.8 ms vs 108.5±55.4 ms; P =0.4) and JTc-D (98.1±41.3 vs 111.4±47.5 vs 105.1±33.4 ms; P =0.3) before, 24 h and 1 month after CoA surgical correction. In conclusions, our study did not show a statistically signif icant decrease in QTc-D and JTc- D, suggesting the hypothesis that the acute left ventricular afterload reduction, related to successful CoA surgical correction, may not reduce the ventricular electrical instability in the short- term follow-up., G. Nigro ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false