Histological aspects of skeletal muscle fibers splitting of C57BL/6NCrl mice

Title:

Histological aspects of skeletal muscle fibers splitting of C57BL/6NCrl mice

Creator:

Makovický, Peter and Makovický, Pavol

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ba75cc35-7472-4ede-9b71-8264c102b1f6
uuid:ba75cc35-7472-4ede-9b71-8264c102b1f6
doi:10.33549/physiolres.934245

Subject:

myopathology, skeletal muscle fiber, regeneration, and skeletal muscles

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The objective of the current study is to present data on the splitting of skeletal muscle fibers in C57BL/6NCrl mice. Skeletal muscles (m. rectus femoris (m. quadriceps femoris)) from 500 (250 ♀ and 250 ♂) C57BL/6NCrl mice in the 16th week of life were sampled during autopsy and afterwards standardly histologically processed. Results show spontaneous skeletal muscle fiber splitting which is followed by skeletal muscle fiber regeneration. One solitary skeletal muscle fiber is split, or is in contact with few localized splitting skeletal muscle fibers. Part of the split skeletal muscular fiber is phagocytosed, but the remaining skeletal muscular fiber splits are merged into one regenerating skeletal muscle fiber. Nuclei move from the periphery to the regenerating skeletal muscle fiber center during this process. No differences were observed between female and male mice and the morphometry results document <1 % skeletal muscle fiber splitting. If skeletal muscular fibers splitting occurs 5 %> of all skeletal muscular fibers, it is suggested to describe and calculate this in the final histopathological report.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

291-296

Source:

Physiological research | 2020 Volume:69 | Number:2

Harvested from:

CDK

Metadata only:

false