Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy

Title:

Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy

Creator:

Jung, H., Lee, E., Kim, I., Song, J. H., and Kim, G. J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b8749d93-650f-46dd-ac83-a7d89dc81ad9
uuid:b8749d93-650f-46dd-ac83-a7d89dc81ad9
doi:10.33549/physiolres.934110

Subject:

cardiac hypertrophy, fibrosis, histone deacetylase inhibitors, oxidative stress, vascular endothelium, and ventricular remodeling

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of cardiovascular diseases. We hypothesized that HDAC inhibitor, sodium valproate (VPA), has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy induced by transverse aortic constriction (TAC). Sections of the heart were visualized after hematoxylin and eosin staining, picrosirius red staining and immunohistochemistry. The expression of genes related to cardiac hypertrophy, fibrosis, and oxidative stress was determined by quantitative real-time polymerase chain reaction. The aortic ring tension analysis was conducted using both the ascending aorta and descending thoracic aorta. TAC increased the expression of hypertrophic, fibrotic, and oxidative stress genes, which was attenuated by VPA. In the ascending aorta with intact endothelium, there was a significant decrease in the relaxation response, which was recovered by VPA treatment. These results indicate that VPA has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

727-737

Source:

Physiological research | 2019 Volume:68 | Number:5

Harvested from:

CDK

Metadata only:

false