A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behaviour in Wistar rats

Title:

A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behaviour in Wistar rats

Creator:

Morová, Martina, Senko, Tomáš, Olexová, Lucia, Dzirbíková, Zuzana, and Kršková, Lucia

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b0832eaf-9eba-4691-9af4-71fa63254391
uuid:b0832eaf-9eba-4691-9af4-71fa63254391
doi:10.33549/physiolres.934599

Subject:

phthalate mixture, testosterone, anogenital distance, social behavior, and laboratory rat

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Phthalates are chemicals interfering with the function of testosterone and are suspected to play a role in the emergence of neurodevelopmental diseases. This could be due to interference with brain development for which optimal testosterone levels are essential. We investigated the effect of prenatal and early postnatal exposure to a phthalate mixture on the anogenital distance (AGD), plasma testosterone levels and social behavior in rats. Pregnant rats were exposed to a mixture of diethylhexyl, diisononyl and dibutyl phthalate, each at a dose of 4.5 mg/kg/day, from gestational day 15 to postnatal day 4. A social interaction test was performed to assess sociability in the three ontogenetic stages (weaning, puberty, adulthood). AGD was measured in adulthood to assess changes in prenatal testosterone levels. Plasma testosterone levels were measured in adults by a radioimmunoassay. The total frequency and time of socio-cohesive interactions were decreased in phthalate exposed females in weaning, puberty and adulthood. Phthalate exposed males showed a decrease in the frequency of social interactions in weaning only. Shorter anogenital distance was observed in adult males exposed to phthalates. Decreased testosterone levels were observed in the exposed group in both sexes. Our results suggest that early developmental phthalate exposure may play an important role in the hormonal and behavioral changes associated with several neurodevelopmental diseases.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S489-S498

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false