Increase of nocturnal melatonin levels in hemodialyzed patients after parathyroidectomy - a pilot study

Title:

Increase of nocturnal melatonin levels in hemodialyzed patients after parathyroidectomy - a pilot study

Creator:

Radmila Kancheva, Sylvie Sulková, František Švára, Martin Hill, Kanchev, L., and Ivana Žofková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:aeae3fae-2283-40f0-999b-7a64ac9e6ae6
uuid:aeae3fae-2283-40f0-999b-7a64ac9e6ae6
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, melatonin, hemodialýza, hyperparatyreóza, endocrinology, hemodialysis, hyperparathyreosis, parathyroidectomy, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

In hemodialyzed patients hormonal disturbances are known to occur. However, melatonin levels have not been completely studied. The aim of the study was to find whether changes in calcaemia affect melatonin secretion. For this reason we followed the nocturnal serum concentrations of melatonin and parathyroid hormone (PTH) in 9 hemodialyzed patients (6 women and 3 men, aged 37-65 years) both before and 1-3 months after parathyroidectomy at 6 p.m., 9 p.m., 11 p.m., 2 a.m., 5 a.m. and 7 a.m. At 6 p.m. blood samples to evaluate the levels of calcium and phosphate were also collected. Parathyroidectomy resulted in an increase in nocturnal melatonin levels. As expected, the parathyroidectomy was followed by considerable PTH decrease. PTH showed no nocturnal variation before or after parathyroidectomy. Calcium levels significantly decreased after the operation while phosphate levels increased. In summary, in hemodialyzed patients with hyperparathyroidism, parathyroidectomy significantly increases the nocturnal secretion of melatonin. Relationships between the pineal gland and parathyroid glands have yet to be elucidated., R. Kancheva, S. Sulková, F. Švára, M. Hill, L. Kanchev, I. Žofková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false