The effect of high-calorie meal consumption on oxidative stress and endothelial dysfunction in healthy male adults

Title:

The effect of high-calorie meal consumption on oxidative stress and endothelial dysfunction in healthy male adults

Creator:

Kackov, S., Simundic, A.-M., Nikolac, N., Celap, I., Dukic, L., Ruzic, D., and Bilusic, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:acfafa3d-4bc5-47c9-87fc-1dbf17efcbd3
uuid:acfafa3d-4bc5-47c9-87fc-1dbf17efcbd3

Subject:

Fyziologie člověka a srovnávací fyziologie, postprandiální hyperglykémie, oxidační stres, endoteliální dysfunkce, postprandial hyperglycemia, oxidative stress, endothelial dysfunction, apolipoprotein A5, hepatic lipase, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Several authors have reported the association of postprandial hypertriglyceridemia with oxidative stress, systemic inflammation and endothelial dysfunction. Our aim was to investigate the effect of high-calorie meal on blood markers of oxidative stress and endothelial dysfunction and the association of APOA5-1131T/C and -250G/A hepatic lipase (HL) polymorphisms with postprandial triglyceride response. This study included 102 healthy male volunteers. All participants consumed a high-calorie meal (823 calories, 50 g fat, 28 g protein, 60 g carbohydrates). Total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, hsCRP, TAS and ICAM-1 were measured at fasting state and postprandially. APOA5-1131T/C and -250G/A HL polymorphisms were also determined. Postprandial triglycerides were significantly increased (1.4 (1.1-2.1) vs. 2.4 (1.9-3.3) mmol/l, P<0.001). Average triglyceride increase was 1.0±0.7 mmol/l (65 %). Concentration of triglycerides, HDL- cholesterol, LDL-cholesterol, TAS and ICAM-1 differed significantly between the fasting state and postprandial measurements (P<0.001). However, those differences were within the limits of analytical imprecision. Other parameters did not change 3 h after the meal. Triglycerides response did not differ respective to the APOA5 and HL polymorphisms. Family history of hypertension and acut e myocardial infarction were associated with higher postprandial triglyceride concentrations. Postprandial hypertriglyceridemia is not associated with increased concentrations of hsCRP, TAS and ICAM-1. Furthermore, APOA5-1131T/C and -250G/A HL polymorp hisms are not associated with different postprandial triglyceride response., S. Kackov ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:6

Harvested from:

CDK

Metadata only:

false