The effects of 17β estradiol, 17α estradiol and progesterone on oxidative atress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia

Title:

The effects of 17β estradiol, 17α estradiol and progesterone on oxidative atress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia

Creator:

Ozacmak, V. H. and Sayan, H.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a3618da1-933b-4d8b-9b68-0c94a35e318f
uuid:a3618da1-933b-4d8b-9b68-0c94a35e318f

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, progesteron, mozková ischemie, oxidační stres, physiology, progesterone, brain ischemia, oxidative stress, estradiol, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Neuroprotective effects of estrogens and progesterone have been widely studied in various experimental models. The present study was designed to compare possible neuroprotective effects of 17alpha-estradiol, 17beta-estradiol, and progesterone on oxidative stress in rats subjecte d to global cerebral ischemia. Global cerebral ischemia was induced in ovariectomized female rats by four vessel occlusion for 10 min. Following 72 h of reperfusion, levels of malondialdehyde (MDA, oxidative stress marker), and reduced glutathione (GSH, major endogenous antioxidant) were assessed in hippocampus, striatum and cortex of rats treated with either 17alpha-estradiol, 17beta-estradiol, progesterone or estradiol + progesterone beforehand. Steroid administration ameliorated ischemia-induced decrease in GSH and increase in MDA levels. Our data offers additional evidence that estrogens and progesterone or combination of two exert a remarkable neuroprotective effect reducing oxidative stress., V. H. Ozacmak, H. Sayan., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:6

Harvested from:

CDK

Metadata only:

false