Toxoplasma gondii seropositivity and substance use in US adults

Title:

Toxoplasma gondii seropositivity and substance use in US adults

Creator:

Berrett, Andrew N, Gale, Shawn D, Erickson, Lance D, Thacker, Evan L, Brown, Bruce L, and Hedges, Dawson W

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a013ef41-d8c5-4a6e-b651-440e7717d89c
uuid:a013ef41-d8c5-4a6e-b651-440e7717d89c
issn:1803-6465
doi:10.14411/fp.2018.011

Subject:

toxoplazmóza, tabák, alkoholy, marihuana, kokain, heroin, pervitin, užívání drog, toxoplasmosis, tobacco, alcohols, marijuana, cocaine, methamphetamine, drug abuse, 2, and 59

Type:

model:article and TEXT

Format:

print, počítač, and online zdroj

Description:

The intracellular parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) infects humans resulting in acute toxoplasmosis, an infection that in immunocompetent people is typically mild but results in persistent latent toxoplasmosis. In that T. gondii appears to affect dopamine synthesis and because addicting drugs affect midbrain dopamine transmission, latent toxoplasmosis could influence substance use. Using both the third and continuous National Health and Nutrition Examination Surveys from the US Centers for Disease Control and Prevention, we used logistic regression to test for associations between T. gondii seropositivity and subject self-report of having ever used tobacco, alcohol, marijuana, cocaine, heroin, or methamphetamine. In the third NHANES dataset, which included data for tobacco, alcohol, marijuana and cocaine, T. gondii seropositivity was associated with a reduced likelihood of self-reported marijuana (OR = 0.71 [95% CI: 0.58; 0.87]; p = 0.001) and cocaine use (OR = 0.72 [95% CI: 0.56; 0.91]; p = 0.006). In the continuous National Health and Nutrition Examination Surveys dataset, which included data for all six substances, T. gondii seropositivity was associated with a reduced likelihood of self-reported tobacco (OR = 0.87 [95% CI: 0.76; 1.00]; p = 0.044), marijuana (OR = 0.60 [95% CI: 0.50; 0.72]; p < 0.001), heroin (OR = 0.60 [95% CI: 0.42; 0.85]; p = 0.005) and methamphetamine use (OR = 0.54 [95% CI: 0.38; 0.77]; p = 0.001). We observed interactions between sex and T. gondii seropositivity in the prediction of self-reported use of tobacco and alcohol. Further, T. gondii seropositivity appeared to remove the protective effect of education and economic status against self-reported cigarette smoking. These findings suggest that T. gondii seropositivity may be inversely associated with some but not all types of substance use in US adults., Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Bruce L. Brown, Dawson W. Hedges., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

1-11

Source:

Folia parasitologica | 2018 Volume:65 | Number:1

Harvested from:

CDK

Metadata only:

false