Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats

Title:

Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats

Creator:

Hrenák, J., Arendášová, K., Rajkovičová, R., Aziriová, S., Repová, K., Kristína Krajčírovičová, Peter Celec, Kamodyová, N., Bárta, A., Michaela Adamcová, Ľudovít Paulis, and Fedor Šimko

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9cc32221-4a0a-4b1a-ba16-d5db82b96e06
uuid:9cc32221-4a0a-4b1a-ba16-d5db82b96e06

Subject:

Fyziologie člověka a srovnávací fyziologie, melatonin, oxidační stres, oxidative stress, nephroprotection, doxorubicin, captopril, olmesartan, C21 substance, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Chronic kidney disease (CKD) represents a serious public health problem with increasing prevalence and novel approaches to renal protection are continuously under investigation. The aim of this study was to compare the effect of melatonin and angiotensin II type 2 receptor agonist compound 21 (C21) to angiotensin converting enzyme inhibitor captopril and angiotensin II type 1 receptor blocker olmesartan on animal model of doxorubicin nephrotoxicity. Six groups of 3-month-old male Wistar rats (12 per group) were treated for four weeks. The first group served as a control. The remaining groups were injected with a single dose of doxorubicin (5 mg/kg i.v.) at the same day as administration of either vehicle or captopril (100 mg/kg/day) or olmesartan (10 mg/kg/day) or melatonin (10 mg/kg/day) or C21 (0.3 mg/kg/day) was initiated. After four week treatment, the blood pressure and the level of oxidative stress were enhanced along with reduced glomerular density and increased glomerular size. Captopril, olmesartan and melatonin prevented the doxorubicin-induced increase in systolic blood pressure. All four substances significantly diminished the level of oxidative burden and prevented the reduction of glomerular density and modestly prevented the increase of glomerular size. We conclude that captopril, olmesartan, melatonin and C21 exerted a similar level of renoprotective effects in doxorubicin-induced nephrotoxicity., J. Hrenák ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false