The influence of tolbutamide on fatty acid metabolism in the liver and muscle

Title:

The influence of tolbutamide on fatty acid metabolism in the liver and muscle

Creator:

Chorváthová, V., Ondreička, R., Klvanová, J., and Dzúrik, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9c46edc4-0821-41fb-ba90-166cd01542d3
uuid:9c46edc4-0821-41fb-ba90-166cd01542d3

Subject:

rats, liver, muscle, tolbutamide, and Na-palmitate-l14C metabolism

Type:

article, model:article, and TEXT

Description:

Metabolism of palmitate-14C was studied in the rat liver and muscle incubated with 1 mmol.1-1 tolbutamide in vitro experiments: Tolbutamide reduces the utilization of free fatty acids in the liver by inhibiting their uptake, incorporation into total lipids, and oxidation to 14CC>2. Tolbutamide stimulates the incorporation into the triacylglycerol fraction in individual liver lipid fractions and inhibits the incorporation into the free fatty acid fraction. As in the liver, tolbutamide inhibits the uptake, incorporation into total lipids, and oxidation to 14C02 in the muscle. In individual lipid fractions, tolbutamide only inhibits the incorporation of palmitate into cholesterol esters. It can be concluded that tolbutamide directly interferes with fatty acid metabolism and thus improves glucose utilization and insulin resistance.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:5

Harvested from:

CDK

Metadata only:

false