Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines

Title:

Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines

Creator:

Ivana Dostálová, Kvido Smitka, Hana Papežová, Hana Kvasničková, and Jara Nedvídková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:919b6745-cee8-480f-85d1-1896471b2aa4
uuid:919b6745-cee8-480f-85d1-1896471b2aa4
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, mentální anorexie, inzulín, endocrinology, anorexia nervosa, adipocytokiny, HOMA-R, adipocytokines, homeostasis model assessment of insulin resistance (HOMA-R), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Anorexia nervosa (AN) is characterized by self-induced starvation leading to severe weight and fat loss. In the present study, we measured fasting plasma levels of adiponectin, leptin, resistin, insulin and glucose in 10 women with a restrictive type of AN and in 12 healthy women (C). Insulin sensitivity was determined according to homeostasis model assessment of insulin resistance (HOMA-R). Plasma resistin, leptin and insulin levels were significantly decreased, whereas plasma adiponectin levels were significantly increased in patients with AN compared to the C. HOMA-R was significantly decreased in patients with AN compared to the C group. Plasma adiponectin and leptin concentrations negatively and positively correlated with the body mass index and percentage body fat in both groups. Plasma adiponectin levels were negatively related to plasma insulin levels in the AN group only. In conclusion, we demonstrated that AN is associated with significantly decreased plasma leptin and resistin levels, markedly increased plasma adiponectin levels and increased insulin sensitivity. Plasma leptin and adiponectin levels were related to the body size and adiposity. Hyperadiponectinemia could play a role in increased insulin sensitivity of patients with AN. Neither body size and adiposity nor insulin sensitivity are the major determinants of plasma resistin levels in AN. and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:5

Harvested from:

CDK

Metadata only:

false