Impaired microvascular reactivity and endothelial function in patients with Cushing´s syndrome: influence of arterial hypertension

Title:

Impaired microvascular reactivity and endothelial function in patients with Cushing´s syndrome: influence of arterial hypertension

Creator:

Martin Prázný, Jana Ježková, Horová, E., Lazárová, V., Václav Hána, Jan Kvasnička, Ladislav Pecen, Jan Marek, Jan Škrha, and Michal Kršek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9155a3c2-32b9-4877-ad7f-1855ff89cf9f
uuid:9155a3c2-32b9-4877-ad7f-1855ff89cf9f
issn:0862-8408

Subject:

Patologie. Klinická medicína, fyziologie, Cushingův syndrom, oxidační stres, dopplerovská ultrasonografie, physiology, Cushing's syndrome, oxidative stress, Doppler ultrasonography, vascular reactivity, endothelial function, laser Doppler flowmetry, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of the study was to evaluate skin microvascular reactivity (MVR) and possible influencing factors (fibrinolysis, oxidative stress, and endothelial function) in patients with Cushing’s syndrome. Twenty-nine patients with active Cushing’s syndrome (ten of them also examined after a successful operation) and 16 control subjects were studied. Skin MVR was measured by laser Doppler flowmetry during post-occlusive (PORH) and thermal hyperemia (TH). Malondialdehyde and Cu,Zn-superoxide dismutase were used as markers of oxidative stress. Fibrinolysis was estimated by tissue plasminogen activator (tPA) and its inhibitor (PAI-1). N-acetyl-β-glucosaminidase, E-selectin, P-selectin, and ICAM-1 were used as markers of endothelial function. Oxidative stress and endothelial dysfunction was present in patients with hypercortisolism, however, increased concentration of ICAM-1 was also found in patients after the operation as compared to controls (290.8±74.2 vs. 210.9±56.3 ng.ml-1, p<0.05). Maximal perfusion was significantly lower in patients with arterial hypertension during PORH and TH (36.3±13.0 vs. 63.3±32.4 PU, p<0.01, and 90.4±36.6 vs. 159.2±95.3 PU, p<0.05, respectively ) and similarly the velocity of perfusion increase during PORH and TH was lower (3.2±1.5 vs. 5.2±3.4 PU.s-1, p<0.05, and 0.95±0.6 vs. 1.8±1.1 PU.s-1, p<0.05, respectively). The most pronounced impairment of microvascular reactivity was present in patients with combination of arterial hypertension and diabetes mellitus., M. Prázný, J. Ježková, E. Horová, V. Lazárová, V. Hána, J. Kvasnička, L. Pecen, J. Marek, J. Škrha, M. Kršek., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false