The role of smooth muscle cells in vessel wall pathophysiology and reconstruction using bioactive synthetic polymers

Title:

The role of smooth muscle cells in vessel wall pathophysiology and reconstruction using bioactive synthetic polymers

Creator:

Martin Pařízek, Novotná, K., and Lucie Bačáková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8d032ff9-24e6-4613-9f58-ccd35e7216b5
uuid:8d032ff9-24e6-4613-9f58-ccd35e7216b5

Subject:

Fyziologie člověka a srovnávací fyziologie, tkáňové inženýrství, nanostruktury, tissue engineering, nanostructures, bioartificial vascular grafts, polymer irradiation, dynamic bioreactor, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

This review summarizes recent trends in the construction of bioartificial vascular replacements, i.e. hybrid grafts containing synthetic polymeric scaffolds and cells. In these advanced replacements, vascular smooth muscle cells (VSMC) should be considered as a physiological component, although it is known that activation of the migration and proliferation of VSMC plays an important role in the onset and development of vascular diseases, and also in re stenosis of currently used vascular grafts. Therefore, in novel bioartificial vascular grafts, VSMCs should be kept in quiescent mature contractile phenotype. This can be achieved by (1) appropriate physical and chemical properties of the material, such as its chemical composition, polarity, wettability, surface roughness and topography, electrical charge and conductivity, functionalization with biomolecules and mechanical properties, (2) appropriate cell culture conditions, such as composition of cell culture media and dynamic load, namely cyclic strain, and (3) the presence of a confluent, mature, semipermeable, non-thrombogenic and non-immunogenic endothelial cell (EC) barrier, covering the luminal surface of the graft and separating the VSMCs from the blood. Both VSMCs and ECs can also be differentiated from stem and progenitor cells of various sources. In the case of degradable scaffolds, the material will gradually be removed by the cells and will be replaced by their own new extracellular matrix. Thus, the material component in advanced blood vessel substitute s acts as a temporary scaffold that promotes regeneration of the damaged vascular tissue., M. Pařízek, K. Novotná, L. Bačáková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:3

Harvested from:

CDK

Metadata only:

false