Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women

Title:

Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women

Creator:

Dana Sedláčková, Ivana Dostálová, Vojtěch Hainer, Beranová, L., Hana Kvasničková, Martin Hill, Martin Haluzík, and Jara Nedvídková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:89d2f192-b2b3-4125-865d-bb79c7bffd85
uuid:89d2f192-b2b3-4125-865d-bb79c7bffd85
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, biochemie, endocrinology, biochemistry, obestatin, total ghrelin, acyl ghrelin, desacyl ghrelin, carbohydrate breakfast, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Ghrelin is a gut peptide produced mainly by stomach, well known to induce appetite stimulatory actions. Obestatin, a recently identified peptide derived from preproghrelin, was initially described to antagonize stimulatory effect of ghrelin on food intake. The postprandial response of obestatin and its relationship with ghrelin in humans remains unknown. We therefore investigated the postprandial response of obestatin and total ghrelin, acyl and desacyl ghrelin and neuropeptide Y (NPY) to a high-carbohydrate breakfast (1 604 kJ) in eight healthy women (age: 24.2±0.82 years; BMI 21.6±0.61 kg/m2). Blood samples were collected before the meal, and 30, 60, 90, 120 and 150 min after the breakfast consumption. Postprandial plasma obestatin concentrations significantly decreased compared with preprandial levels as well as total ghrelin concentrations and reached the lowest values 90 and 120 min after the meal consumption, respectively (p 0.05). Plasma acyl and desacyl ghrelin concentrations decreased after the breakfast and reached lowest values in 30 and 60 min, respectively (p<0.05). Plasma NPY concentrations were lower than preprandial levels 90 and 150 min after consuming breakfast (p<0.05). In conclusion, we demonstrated in healthy young women that plasma obestatin concentrations decrease similarly to ghrelin after a high-carbohydrate breakfast., D. Sedláčková, I. Dostálová, V. Hainer, L. Beranová, H. Kvasničková, M. Hill, M. Haluzík, J. Nedvídková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false