N-acetylcysteine treatment prevents the up-regulation of Mn SOD in chronically hypoxic rat hearts

Title:

N-acetylcysteine treatment prevents the up-regulation of Mn SOD in chronically hypoxic rat hearts

Creator:

Balková, P., Hlaváčková, M., Marie Milerová, Jan Neckář, František Kolář, Novák, F., and Nováková, O.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:86fc1c60-b5e6-415b-9a17-6d3df32d9fb4
uuid:86fc1c60-b5e6-415b-9a17-6d3df32d9fb4

Subject:

Fyziologie člověka a srovnávací fyziologie, ischemie, infarkt myokardu, ischemia, myocardial infarction, chronic hypoxia, MnSOD, ischemia/reperfusion, cardioprotection, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Chronic intermittent hypoxia (CIH ) is associated with increased production of reactive oxygen species that contributes to the adaptive mechanism underlying the improved myocardial ischemic tolerance. The aim was to find out whether the antioxidative enzyme manganese superoxide dismutase (MnSOD) can play a role in CIH-induced cardioprotection. Adult male Wistar rats were exposed to intermittent hypobaric hypoxia (7000 m, 8 h/day, 25 exposures) (n=14) or kept at normoxia (n=14). Half of the animals from each group received N-acetylcysteine (NAC, 100 mg/kg) daily before the hypoxic exposure. The activity and expression of MnSOD were increased by 66 % and 23 %, respectively, in the mitochondrial fraction of CIH hearts as compared with th e normoxic group; these effects were suppressed by NAC treatment. The negative correlation between MnSOD activity and myoc ardial infarct size suggests that MnSOD can contribute to the improved ischemic tolerance of CIH hearts., P. Balková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:3

Harvested from:

CDK

Metadata only:

false