Preconditioning with whole-body or regional hyperthermia attenuates exercise-induced muscle damage in rodents

Title:

Preconditioning with whole-body or regional hyperthermia attenuates exercise-induced muscle damage in rodents

Creator:

Mikami, Toshio and Yamauchi, Hideki

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:86b5c97a-9a46-4be2-8c7e-9fe379eaef85
uuid:86b5c97a-9a46-4be2-8c7e-9fe379eaef85
doi:10.33549/physiolres.934569

Subject:

heat shock protein, hyperthermia, microwave treatment, muscle damage, creatine kinase, β-glucuronidase, and eccentric exercise

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Our aim was to investigate whether hyperthermia before exercise protects against exercise-induced skeletal muscle damage. Two hyperthermia protocols were evaluated. In the first, male ICR mice were exposed to 30 min of whole-body heat in an environmental chamber at an ambient temperature of 42 °C. Heat-exposed and non-heat-exposed mice subsequently completed 60 min of downhill running on a treadmill, 24 h after exposure. Heat exposure significantly increased HSP70 and HSP25 content in the soleus muscle compared to controls. Plasma creatine kinase, muscle β-glucuronidase, and histochemical (hematoxylin and eosin stain) analysis demonstrated that muscle damage was lower in the heatexposed mice than in the non-heat-exposed mice. In the second, the effect of regional heating of the legs, by microwave diathermy, on the prevention of exercise-induced muscle damage was evaluated in male Wistar rats. Microwave-treated and nonmicrowave-treated rats again completed the running protocol 24 h after exposure. Microwave diathermy increased the muscle temperature to 40 °C, significantly increased HSP70 and HSP25 content in the soleus muscle, and significantly attenuated exercise-induced muscle damage. Therefore, hyperthermia before exercise increases skeletal muscle HSPs and attenuates the risk of exercise-induced muscle injury.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

125-134

Source:

Physiological research | 2022 Volume:71 | Number:1

Harvested from:

CDK

Metadata only:

false