Antioxidant defense is increased in aged hearts following omega-3 supplementation in the absence of changes in inflammation

Title:

Antioxidant defense is increased in aged hearts following omega-3 supplementation in the absence of changes in inflammation

Creator:

Lennon-edwards, S., Schellhardt, T. A., and Kuczmarski, J. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8696d0ff-684c-4a4d-a6b3-8dcc5bb28d87
uuid:8696d0ff-684c-4a4d-a6b3-8dcc5bb28d87
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, stárnutí, oxidační stres, omega-3 mastné kyseliny, záněty, aging, oxidative stress, inflammations, omega-3 fatty acids, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The purpose of this study was to determine the effect of a 15-week omega-3 rich diet on age-related differences in myocardial antioxidant defense and inflammation. 20 mature (M) (6 mo.) and 20 old (O) (15 mo.) male Fisher 344 rats were assigned to two diet groups: Control (CON) or Fish Oil (FO). Following the diet, animals were sacrificed and left ventricular (LV) heart tissue was harvested for biochemical assays and western blot analysis. No differences were observed in expression of LV interleukin-6 (IL-6) and tumor necrosis factor-α as well as hydrogen peroxide (H2O2) production between MCON and OCON. However, LV catalase protein expression and activity were increased in OCON vs. MCON and accompanied by increased expression of superoxide dismutase (SOD)-1. In contrast, LV IL-6 was lower in MFO vs. old rats, and LV H2O2 was decreased in MFO and OFO relative to respective control groups. Protein expression and activity of LV catalase and SOD-1 expression were increased in OFO similarly to OCON, but LV SOD activity was also increased in OFO vs. mature rats. In summary, FO supplementation increased myocardial antioxidant defense in all animals and augmented age-associated increases in antioxidant capacity in the absence of changes in inflammation., S. Lennon-Edwards, T. A. Schellhardt, J. M. Kuczmarski., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:3

Harvested from:

CDK

Metadata only:

false