Cellular and nerve fibre catecholaminergic thymic network: steroid hormone dependent activity

Title:

Cellular and nerve fibre catecholaminergic thymic network: steroid hormone dependent activity

Creator:

Leposavić, G., Pilipović, I., and Perišić, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:84ff4a9c-c7b6-425d-92d4-487286909fa6
uuid:84ff4a9c-c7b6-425d-92d4-487286909fa6

Subject:

Fyziologie člověka a srovnávací fyziologie, brzlík, sexuální dimorfismus, glukokortikoidy, thymus, sexual dimorphism, glucocorticoids, catecholamines, adrenoceptors, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adap tive immunity. Thymic T-cell development is influenced by loca lly produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non- lymphoid cells have been shown not only to express β - and α 1 - adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/ paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine- immune communications at thymic level., G. Leposavić, I. Pilipović, M. Perišić., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false