Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Title:

Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

Creator:

Garnol, T., Endlicher, R., Kučera, O., Zdeněk Drahota, and Červniková, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7fc1adad-d953-4afc-b84f-5a29275644dc
uuid:7fc1adad-d953-4afc-b84f-5a29275644dc

Subject:

Fyziologie člověka a srovnávací fyziologie, mitochondrie, stres (fyziologie), mitochondrias, stress (physiology), hepatocytes, high/fat diet, mitochondrial activities, ROS, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Fatty liver disease associated with obesity is an important medical problem and the mechanisms for lipid accumulation in hepatocytes are not fully elucidated yet. Recent findings indicate that mitochondria play an importan t role in this process. Our data on hepatocytes in which mitochondria are in contact with other cytosolic structures importan t for their function, extend observations obtained on isolated mitochondria and confirm inhibition of Complex I activity in hepatocytes isolated from rats fed by high fat diet (HFD) compared with controls fed by standard diet (STD). Furthermore we have found that HFD- hepatocytes are more sensitive to the peroxidative stress because under these conditions also Complex II activity is disturbed. Therefore in HFD animals decrease of Complex I activity cannot be compensated by Complex II substrates as in STD hepatocytes. Our data thus indicates that combination of HFD and peroxidative stress potentiates HFD damaging effect of mitochondria because both branches of the respiratory chain (NADH- and flavoprotein-dependent) are disturbed., T. Garnol ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:2

Harvested from:

CDK

Metadata only:

false