Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults

Title:

Overweight and decreased baroreflex sensitivity as independent risk factors for hypertension in children, adolescents, and young adults

Creator:

Krontorádová, K., Nataša Honzíková, Bohumil Fišer, Zuzana Nováková, Eva Závodná, Hana Hrstková, and Petr Honzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7c69a831-9ec6-42c8-ab8b-9ddee8bf8de6
uuid:7c69a831-9ec6-42c8-ab8b-9ddee8bf8de6
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, krevní tlak, nadváha, hypertenze, adolescenti, physiology, blood pressure, overweight, hypertension, adolescents, baroreflex sensibility, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We studied the relationship between blood pressure (BP), body mass index (BMI, kg/m2) and baroreflex sensitivity (BRS, ms/mmHg) in adolescents. We examined 34 subjects aged 16.2±2.4 years who had repeatedly high causal BP (H) and 52 controls (C) aged 16.4±2.2 years. Forty-four C and 22 H were of normal weight (BMI between 19-23.9), and 8 C and 12 H were overweight (BMI between 24-30). Systolic BP was recorded beat-to-beat for 5 min (Finapres, controlled breathing 0.33 Hz). BRS was determined by the cross-spectral method. The predicting power of BMI and BRS for hypertension was evaluated by sensitivity, specificity, and receiver operating curve (ROC - plot of sensitivity versus specificity). H compared with C had lower BRS (p<0.01) and higher BMI (p<0.05). Multiple logistic regression analysis (p<0.001) revealed that a decreased BRS (p<0.05) and an increased BMI (p<0.01) were independently associated with an increased risk of hypertension. No correlation between BMI and BRS was found either in H or in C. Following optimal critical values by ROC, the sensitivity, specificity and area under ROC were determined for: BMI - 22.2 kg/m2, 61.8 %, 69.2 %, 66.0 %; BRS - 7.1 ms/mmHg, 67.7 %, 69.2 %, 70.0 %; BMI and BRS - 0.439 a.u., 73.5 %, 82.7 %, and 77.3 %. Decreased BRS and overweight were found to be independent risk factors for hypertension., K. Krontorádová, N. Honzíková, B. Fišer, Z. Nováková, E. Závodná, H. Hrstková, P. Honzík., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false