Hepatic monooxygenases and conjugating enzymes in cadmium-intoxicated hamsters: effect of vitamin C supplementation

Title:

Hepatic monooxygenases and conjugating enzymes in cadmium-intoxicated hamsters: effect of vitamin C supplementation

Creator:

Nagyová, A., Ginter, E., Štefek, M., and Yanev, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:794e8608-25ad-4e89-b52d-0cd625025f06
uuid:794e8608-25ad-4e89-b52d-0cd625025f06

Subject:

cytochrome P-450, cadmium, vitamin C, hamsters, and hepatic monooxygenases

Type:

article, model:article, and TEXT

Description:

The effects of cadmium and simultaneous administration of cadmium and vitamin C on hepatic microsomal monooxygenase activities, conjugation enzyme activities and enzyme activities in the serum were investigated in hamsters. Cadmium, as cadmium chloride, was administered to hamsters in a subtoxic dose in drinking water (10 mg Cd per liter) for 10 weeks. The majority of hepatic microsomal monooxygenases and enzyme activities in the serum reflecting liver damage were not significantly affected by subchronic cadmium treatment. On the other hand, cytosolic glutathione S-transferase and serum alanine aminotransferase were significantly changed by cadmium and these changes were effectively eliminated by the simultaneous administration of vitamin C (1 g per liter of drinking water). The results indicate that long-term supplementation with vitamin C may be effective in the protection of hepatic enzymes against cadmium toxicity.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:6

Harvested from:

CDK

Metadata only:

false