Phospholipid composition in the rat heart exposed to pressure overload from birth

Title:

Phospholipid composition in the rat heart exposed to pressure overload from birth

Creator:

mrnka, L., Nováková, O., Pelouch, V., and Novák, F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:76392491-992c-4c30-813a-373697da0aea
uuid:76392491-992c-4c30-813a-373697da0aea

Subject:

myocardium, pressure overload, aorta banding, hypertrophy, postnatal development, phospholipids, and plasmalogens

Type:

article, model:article, and TEXT

Description:

A pressure overload was induced in 2-day-old male rats by abdominal aortic constriction, and the phospholipid composition of the left ventricle (LV) and the right ventricle (RV) were determined. Sixty days after the surgery, body weights was lower and LV weight were higher in aorta-constricted (AC) rats in comparison with sham- operated animals. Increased ventricular/body weight ratios indicated a significant degree of hypertrophy of LV and smaller hypertrophy of RV. The concentrations of total phospholipids (PL), choline phosphoglycerides (PC), ethanolamine phosphoglycerides (PE), diphosphatidylglycerol (DPG) and phosphatidylinositol (PI) were decreased in both ventricles of AC rats. The concentrations of sphingomyelin (SM) and plasmalogen PE (PLPE) increased in LV only. The changes in phospholipid composition in the developing pressure-overloaded myocardium may contribute to altered membrane functions connected with heart hypertrophy.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:1

Harvested from:

CDK

Metadata only:

false